Th2 Modulator

The PureResponse^™ formula Th2 Modulator is designed to support healthy Th1/Th2 balance and mucosal health. Modulating Th2 status helps to maintain Th1/Th2 balance and offers support for self-tissue response. Th2 response is affected by stress, aging, and cytokine changes resulting from metabolic, hormonal, physiological, and environmental factors. The product helps support healthy modulation of Th2 cytokines, and eosinophil and mast cell activity. It also helps maintain healthy modulation of mucosal immune responses to environmental factors. Th2 modulation may be indicated when addressing immune balance in the sinus, respiratory, urinary, and intestinal tracts. Perilla maintains healthy upper respiratory cytokine levels in animal models of Th2 dominance. It also supports cytokine homeostasis of GI mucosal tissue. In a randomized controlled trial involving 50 individuals, 150 mg of Perilla frutescens extract twice daily offered statistically significant support for GI comfort. N-acetyl-l-cysteine (NAC) offers mucolytic properties and promotes tissue levels of glutathione – a key component of the antioxidant defense system – to support the body’s natural defense system. Lymphocytes rely on glutathione to function properly. It is believed to be through this antioxidant mechanism that NAC supports healthy Th1/Th2 balance and cytokine production to maintain tissue health. A multicenter, randomized, double-blind trial with 262 participants indicated that NAC supplementation for six months supported upper respiratory tract and immune system health. Quercetin is known for its antioxidant activity and immune support properties, including support for Th1/Th2 balance and cytokine balance. Astragalus may help modulate the relationship between Th1 and Th2 cytokines.^‡