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Unfair Advantage – 1 package contains 30 oral dispensers, each dispenser contains 10mL (30 servings)

Enhances mitochondrial function, your cells’ power plants. Helps make the energy you need for peak performance!

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Unfair Advantage ~ 1 Carton – 30 Mini-Shots

Helps Make The Energy You Need For Peak Performance!


  • √ Helps make the energy you need for peak mental and physical performance
  • √ Promotes heart cell and nerve cell function
  • √ Increases mitochondria biogenesis and enhances mitochondrial function, your cells’ power plants
  • √ Bio-identical ActivePQQ™ and CoQ10
  • √ Proprietary liposomal delivery system uses Brain Octane® oil and other special fats to help your body preferentially absorb Active PQQ™ and CoQ10 to power peak performance


  • 1 package of Unfair Advantage containing 30 Mini-Shots™ (30-day supply)
  • 30 Ampules Net Contents 120 ML

Overview & Benefits

Your cells contain mitochondria (power plants) that directly create the energy that is fundamental to life itself. You can help to achieve your maximum mental and physical potential by making your mitochondria better. Stronger mitochondria make for stronger brains and stronger bodies.. Unfortunately, the enormous amount of energy produced by your mitochondria make them susceptible to free radical damage and decay as you age.[8-10]

Until recently, the only known way to increase the effectiveness of your mitochondria was to perform exhausting physical workouts, train at high altitude, or practice extreme caloric restriction. (Well, there’s also The Bulletproof Diet…)

But there’s another way…

You can supercharge your mitochondria with an instant “shortcut” that delivers a brand new, activated form of a cellular nutrient called pyrroloquinoline quinine – commonly known as PQQ. Adding the new ActivePQQ™ form of this “missing link” to your brain and body can make you feel like you’re flipping on a switch of clean-burning energy.

This is where Unfair Advantage™ comes in.

PQQ in the disodium salt form is often degraded by stomach acid reducing bioavailability and absorption. Which means that you may not get the potential benefits at a cellular level. Unfair Advantage PQQ uses a proprietary pre-colloidal delivery technology to create ultra-fine particles of ActivePQQ ™. By delivering the right form of PQQ with the right delivery system, the bioavailability and absorption of this product is enhanced, supporting your mitochondrial health.

When you open up the Mini-Shot™ and swallow about a teaspoon of Unfair Advantage, it quickly goes to work recharging your mitochondria to renew your body and mind at a cellular level.

Unfair Advantage has such a profound effect on your mental and physical energy, even though it doesn’t contain a trace of caffeine or any other common “stimulant”…

This ground-breaking delivery method will give you a energy boost from your mitochondria pumping out more power for your body, and brain, to help you perform at your highest level.



Pyrroloquinoline quinone increases the expression and activity of Sirt1 and -3 genes in HepG2 cells.

Zhang J, Meruvu S, Bedi YS, Chau J, Arguelles A, Rucker R, Choudhury M.

Nutr Res. 2015 Sep;35(9):844-9. doi: 10.1016/j.nutres.2015.06.014. Epub 2015 Jul 2.

PMID: 26275361 [PubMed – in process]

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Pyrroloquinoline quinone (PQQ) producing Escherichia coli Nissle 1917 (EcN) alleviates age associated oxidative stress and hyperlipidemia, and improves mitochondrial function in ageing rats.

Singh AK, Pandey SK, Saha G, Gattupalli NK.

Exp Gerontol. 2015 Jun;66:1-9. doi: 10.1016/j.exger.2015.04.001. Epub 2015 Apr 2.

PMID: 25843018 [PubMed – in process]

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Protective Effect of Pyrroloquinoline Quinone (PQQ) in Rat Model of Intracerebral Hemorrhage.

Lu H, Shen J, Song X, Ge J, Cai R, Dai A, Jiang Z.

Cell Mol Neurobiol. 2015 Oct;35(7):921-30. doi: 10.1007/s10571-015-0187-5. Epub 2015 Mar 29.

PMID: 25820784 [PubMed – in process]

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Effects of dietary pyrroloquinoline quinone disodium on growth, carcass characteristics, redox status, and mitochondria metabolism in broilers.

Wang J, Zhang HJ, Samuel KG, Long C, Wu SG, Yue HY, Sun LL, Qi GH.

Poult Sci. 2015 Feb;94(2):215-25. doi: 10.3382/ps/peu050. Epub 2015 Jan 20.

PMID: 25609689 [PubMed – in process]

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Pyrroloquinoline quinone protects nucleus pulposus cells from hydrogen peroxide-induced apoptosis by inhibiting the mitochondria-mediated pathway.

Yang L, Rong Z, Zeng M, Cao Y, Gong X, Lin L, Chen Y, Cao W, Zhu L, Dong W.

Eur Spine J. 2015 Aug;24(8):1702-10. doi: 10.1007/s00586-014-3630-2. Epub 2014 Oct 28.

PMID: 25349108 [PubMed – in process]

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Pyrroloquinoline quinone protects mouse brain endothelial cells from high glucose-induced damage in vitro.

Wang Z, Chen GQ, Yu GP, Liu CJ.

Acta Pharmacol Sin. 2014 Nov;35(11):1402-10. doi: 10.1038/aps.2014.4. Epub 2014 Oct 6.

PMID: 25283505 [PubMed – indexed for MEDLINE] Free PMC Article

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Involvement of ERK1/2 pathway in neuroprotective effects of pyrroloquinoline quinine against rotenone-induced SH-SY5Y cell injury.

Zhang Q, Zhang J, Jiang C, Qin J, Ke K, Ding F.

Neuroscience. 2014 Jun 13;270:183-91. doi: 10.1016/j.neuroscience.2014.04.022. Epub 2014 Apr 19.

PMID: 24755484 [PubMed – indexed for MEDLINE]

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Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.

Harris CB, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, Rucker RB.

J Nutr Biochem. 2013 Dec;24(12):2076-84. doi: 10.1016/j.jnutbio.2013.07.008.

PMID: 24231099 [PubMed – indexed for MEDLINE] Free Article

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Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats.

Bauerly K, Harris C, Chowanadisai W, Graham J, Havel PJ, Tchaparian E, Satre M, Karliner JS, Rucker RB.

PLoS One. 2011;6(7):e21779. doi: 10.1371/journal.pone.0021779. Epub 2011 Jul 21.

PMID: 21814553 [PubMed – indexed for MEDLINE] Free PMC Article

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Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.

Chowanadisai W, Bauerly KA, Tchaparian E, Wong A, Cortopassi GA, Rucker RB.

J Biol Chem. 2010 Jan 1;285(1):142-52. doi: 10.1074/jbc.M109.030130. Epub 2009 Oct 27.

PMID: 19861415 [PubMed – indexed for MEDLINE] Free PMC Article

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Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes.

Tao R, Karliner JS, Simonis U, Zheng J, Zhang J, Honbo N, Alano CC.

Biochem Biophys Res Commun. 2007 Nov 16;363(2):257-62. Epub 2007 Aug 14.

PMID: 17880922 [PubMed – indexed for MEDLINE] Free PMC Article

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Pyrroloquinoline quinone nutritional status alters lysine metabolism and modulates mitochondrial DNA content in the mouse and rat.

Bauerly KA, Storms DH, Harris CB, Hajizadeh S, Sun MY, Cheung CP, Satre MA, Fascetti AJ, Tchaparian E, Rucker RB.

Biochim Biophys Acta. 2006 Nov;1760(11):1741-8. Epub 2006 Jul 25.

PMID: 17029795 [PubMed – indexed for MEDLINE]

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Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury.

Zhu BQ, Simonis U, Cecchini G, Zhou HZ, Li L, Teerlink JR, Karliner JS.

J Cardiovasc Pharmacol Ther. 2006 Jun;11(2):119-28.

PMID: 16891289 [PubMed – indexed for MEDLINE]

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Pyrroloquinoline quinone modulates mitochondrial quantity and function in mice.

Stites T, Storms D, Bauerly K, Mah J, Harris C, Fascetti A, Rogers Q, Tchaparian E, Satre M, Rucker RB.

J Nutr. 2006 Feb;136(2):390-6.

PMID: 16424117 [PubMed – indexed for MEDLINE] Free Article

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Antioxidant and pro-oxidant properties of pyrroloquinoline quinone (PQQ): implications for its function in biological systems.

He K, Nukada H, Urakami T, Murphy MP.

Biochem Pharmacol. 2003 Jan 1;65(1):67-74.

PMID: 12473380 [PubMed – indexed for MEDLINE]

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Ingredients & Use

Unfair Advantage™ pairs Active PQQ™ (a unique composition of Pyrroloquinoline quinone) with CoQ10 in a synergistic energy formula. Unfair Advantage™ uses patented technologies for maximum bioavailability, including colloidal and pre-colloidal delivery systems to fuel the body and brain with active ingredients, which means a noticeable effect so you can perform your best.

Ingredients: Ingredients: Purified water, glycerin, caprylic acid triglycerides from highly refined coconut oil (Bulletproof Brain Octane oil), natural flavors, phosphatidylcholine, palmitic acid, oleic acid, ubiquinone, pyrroloquinoline quinone, gum arabic, xanthan gum. All ingredients are non-GMO, product contains no fillers, dyes or other junk.

For enhanced mental performance: Take 1–2 Mini-Shots™ per day.
For enhanced sports performance: Take 2–4 Mini-Shots™ per day.

Natural separation may occur, please shake gently before opening the Mini-Shot™ and consuming.

Warning: If you are 18 years or younger, pregnant or lactating, on medication (including blood pressure medication), have a medical condition, or are allergic to any listed ingredients, please consult your health care practitioner before using this product. Do not use if safety seal is broken or missing.

Shelf Life: Refer to expiration date on your package

Science & Research

Active PQQ™ is a special form of PQQ that’s custom synthesized during the manufacturing process for Unfair Advantage™. PQQ supplements available at your local health food store are in the disodium salt form of PQQ, which is well studied in animals with positive effects, but the effects are dramatically reduced for humans because this particular form precipitates out in an acidic environment like your stomach. This means you don’t absorb it effectively, and don’t feel the effects you should.

When Bulletproof synthesized Active PQQ™ in the lab, we used an acid form of PQQ that isn’t as susceptible to precipitating out in your stomach. Because delivery mechanisms are so important for high end supplements, Unfair Advantage™ uses Active PQQ™ in a pre-colloidal and colloidal suspension where the molecules are so small they are suspended in water, this also works to improve absorption.

The Active PQQ™ is then paired with CoQ10, a well known enhancer of mitochondrial function to increase the overall effects. Both CoQ10 and PQQ occur naturally in the body, and Active PQQ™ is the most natural form. This is the exact kind of PQQ that your body produces. You may have heard of bio-identical testosterone, and Unfair Advantage™ has bio-identical PQQ, which is not found in other supplements.

PQQ and CoQ10 work well together, and when they are both made into incredibly small molecules in a liquid suspension, it absorbs dramatically well. Unfair Advantage™has a 2:1 ratio of CoQ10 to ActivePQQ.

In the Colloidial form CoQ10 is more effective, so you can use less.

There is nothing quite like the feeling you get when your mitochondria turn on. This is the cellular energy that affects your brain first, where you have a very dense amount of mitochondria.

Unfair Advantage™ also increases mitochondria biogenesis, your body’s ability to create new, more effective mitochondria. This means that your body will understand that it will benefit from having better power plants in your cells, and will clear out old mitochondria and replace it with new mitochondria.[6] It also boosts energy production and function of existing mitochondria.


  1. Protection of pyrroloquinoline quinone against methylmercury-induced neurotoxicity via reducing oxidative stress
  2. Nakano M, Ubukata K, Yamamoto T, Yamaguchi H (2009) Effect of pyrroloquinoline quinone (PQQ) on mental status of middle-aged and elderly persons. FOOD style. 21 13, 50-53
  3. Stimulation of Nerve Growth Factor Production by Pyrroloquinoline Quinone and Its derivatives in Vitro and in Vivo
  4. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation.
  5. Ubiquinol-Induced Gene Expression Signatures are Translated into Altered Parameters of Erythropoiesis and Reduced Low Density Lipoprotein Cholesterol Levels in Humans
  6. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.
  7. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects
  8. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases.
  9. Mitochondrial metabolic function assessed in vivo and in vitro.
  10. Mitochondrial-nuclear epistasis: implications for human aging and longevity.

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